Abstract Tumour DNA sequencing is essential for precision medicine since it guides therapeutic decisions but also fosters the identification of patients who may benefit from germline testing.Notwithstanding, the tumour-to-germline testing workflow presents a few caveats.The low sensitivity for indels at loci with sequences of identical bases (homop

Prion diseases, including chronic wasting disease (CWD), are caused by prions, which are misfolded aggregates of normal cellular prion protein.Prions possess many characteristics that Tea Cup distinguish them from conventional pathogens, in particular, an extraordinary recalcitrance to inactivation and a propensity to avidly bind to surfaces.In mid

In this work, new biodegradable ABCBA type pentablock copolymers with different mole ratio of L-lactide and PPDO-b-PEG-b-PPDO triblock copolymer were synthesized and characterized.In the first step, PPDO-b-PEG-b-PPDO triblock copolymer was synthesized via a ring-opening polymerization of P-DiOxanone (PDO) monomer with Poly (Ethylene Glycol) (PEG) u

Currently, some catastrophe models used by the insurance industry account for liquefaction by applying a simple factor to shaking-induced losses.The factor is based only on local liquefaction susceptibility and this highlights the need for a more sophisticated approach to incorporating the effects of liquefaction in loss models.This study compares

Wetlands are sensitive and valuable ecosystems but today their safety and their sustainability have been harshly influenced by various natural and human factors.Using environmental risk assessment is an important tool in studies of environmental management and recognition and reduction of the potentially harmful environmental factors to achieve sus